Phyrexia will definatly be up there as most likely (ofcoarse watch the set be nearly all modern playable cards again like last time)
Heck in maro if/when day from this year a few weeks ago had poison counters in standard and 2.0 version of the praetors was a Big when
Anyway besides core 2022 probably karn like you said if we’re going to New Phyrexia again
Probably a new plane again and one revisit
And I feel commander 2021 will be on New Phyrexia because elesh norn probably becoming the New heir to yawgmoth throne and that gives opportunity for a phyrexia themed deck
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Card Previews
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Skithiryx with the Legendary border plus new extended art