Your defense against opposing flyers is very weak. 2/2 flying Primal Clays just don't cut it, when you can expect 3/3s, 4/4s, 5/5s, and even bigger beasties to soar over your ground defenses.
I can see, how you want to mill yourself for the LabMan win, but with no tutor for the Maniac, you have to draw into one first, before you can start milling serously. A good tutor for your approach would be Drift of Phantasms, since it also inceases your defender count and it can block bigger stuff in the air.
Personally, however, I would go about the selfmilling differently. Using the numerous variants of Returned Centaur in blue and black accross the whole spectrum of converted mana costs, gives you a large number of creatures to both defend yourself and threaten your opponents. Even if you don't attempt to win with combat damage, the possibility is there. A large number of creatures also opens the path for using Dread Return from the graveyard to reanimate a Maniac when you've emptied your library, which means, you can mill yourself from the very beginning without fear of not getting one.
Another selfmilling tool is dredge. Stinkweed Imp provides good defense, and you can get any copies of it from the graveyard by milling yourself even more. In general, cards that can be used from the graveyard through abilities like dredge, retrace and flashback let you profit from the mill, that you are doing anyway, by giving you more options. For example, even if your board has been cleared, casting Worm Harvest from the graveyard via retrace, gives you the creatures nessessary to flashback Dread Return to return the Maniac. Dredging Dakmor Salvage even gives you the land needed for retrace. Then all you need is a single draw effect.
You could also use Tortured Existence as a way to use your graveyard as a giant tutor pile, if you run creatures with various ETB effects, like Nekrataal, Mulldrifter, etc. I have a whole deck build around that idea, and once recurred a single Nekrataal over and over again turn after turn via dredging a Stinkweed Imp, saccing the 'taal, and switching the two with TE. The enchantment can also get you back a Maniac when you are ready to close the game.
Cards like Chronic Flooding, Pilfered Plans, Disrupt, and Psychic Drain are just not very good. You're spending a lot of cards and mana just to mill yourself slowly, without interacting with what the opponent is doing. Milling is also not good until you have a Lab Man out, otherwise you might just mill all your Lab Maniacs away and have no win condition! It's better to have cards that both interact with the opponent (or provide defense) and advance your gameplan (find Lab Man or mill yourself).
Drift of Phantasms and Stinkweed Imp are good, as already mentioned. Drift can either block OR find Lab Maniac, so it has 2 purposes. Stinkweed Imp can block and kill things and also mill you, so again it does 2 things. That's better than running a card that just mills you and does nothing else.
For a draw spell, Forbidden Alchemy is great at both digging through your library and milling you! And you can flashback copies you milled or cast. Fact or Fiction is great too. These spells will help you dig through your library to find the cards you want more efficiently. I would still run Opt because it lets you win immediately when you have no library, but Forbidden Alchemy and Fact or Fiction are much better than Pilfered Plans and some other cards.
Nephalia Drownyard is a reusable mill card you can fit into your manabase. You don't have to waste a spell slot on it. If you have extra mana and nothing else to do, you can use Drownyard to mill.
You want a way to return Lab Maniacs that were killed or milled. Dread Return is one way, but it is kind of combo-y and makes you suicide your own board. It's not so good if you don't plan to win that very turn. Corpse Churn is one way you can both mill yourself and bring back any Lab Maniacs you accidentally milled away. Liliana, Death's Majesty is another card that can both mill you and return any dead Lab Maniacs or walls. It also makes blockers and wipes the board, but it may be out of your budget.
Phenax, God of Deception works well to mill players when you're playing a Defender deck! You can also switch to milling the opponent if you want. It's a great win condition.
Just to provide a bit more explanation as to why some of the card choices aren't very good, if you're playing cards designed to mill an opponent and targeting yourself with them, laboratory maniac is just an additional step required to win. You could have just as easily targeted your opponent and won through them not having cards in their library. Where Laboratory Maniac becomes good is when you use cards that turn you milling yourself into value. Examples would be Undercity Informer with no lands in your deck, nomads en-kor + cephalid Illusionist, or dredge creatures with draw and discard spells. In addition, these strategies let you play Dread Return and Narcomoeba allowing you to get Labratory maniac from the graveyard easily after it has been milled.
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2 Jace, Memory Adept ($12.00)
3 Traumatize ($5.25)
4 Laboratory Maniac ($6.00)
3 Doorkeeper ($0.36)
4 Disrupt ($1.40)
4 Opt ($1.40)
3 Primal Clay ($0.45)
2 Returned Phalanx ($0.30)
4 Wall of Frost ($1.00)
2 Psychic Drain ($0.90)
3 Chronic Flooding ($0.45)
2 Pilfered Plans ($0.30)
10 Island ($1.40)
10 Swamp ($1.40)
2 Sunken Hollow ($4.32)
2 Frozen Swamp ($1.98)
10 Island
10 Swamp
2 Sunken Hollow
2 Frozen Swamp
Creatures (16)
2 Returned Phalanx
3 Doorkeeper
4 Laboratory Maniac
4 Wall of Frost
3 Primal Clay
4 Opt
4 Disrupt
3 Chronic Flooding
2 Pilfered Plans
2 Jace, Memory Adept
3 Traumatize
2 Psychic Drain
What card is "Frozen Swamp" meant to be? Snow-Covered Swamp?
Former Rules Advisor
"Everything's better with pirates." - Lodge
(The Gamers: Dorkness Rising)
"Any sufficiently analyzed magic is indistinguishable from science."
(Girl Genius - Fairy Tale Theater Break - Cinderella, end of volume 8)
I can see, how you want to mill yourself for the LabMan win, but with no tutor for the Maniac, you have to draw into one first, before you can start milling serously. A good tutor for your approach would be Drift of Phantasms, since it also inceases your defender count and it can block bigger stuff in the air.
Personally, however, I would go about the selfmilling differently. Using the numerous variants of Returned Centaur in blue and black accross the whole spectrum of converted mana costs, gives you a large number of creatures to both defend yourself and threaten your opponents. Even if you don't attempt to win with combat damage, the possibility is there. A large number of creatures also opens the path for using Dread Return from the graveyard to reanimate a Maniac when you've emptied your library, which means, you can mill yourself from the very beginning without fear of not getting one.
Another selfmilling tool is dredge. Stinkweed Imp provides good defense, and you can get any copies of it from the graveyard by milling yourself even more. In general, cards that can be used from the graveyard through abilities like dredge, retrace and flashback let you profit from the mill, that you are doing anyway, by giving you more options. For example, even if your board has been cleared, casting Worm Harvest from the graveyard via retrace, gives you the creatures nessessary to flashback Dread Return to return the Maniac. Dredging Dakmor Salvage even gives you the land needed for retrace. Then all you need is a single draw effect.
You could also use Tortured Existence as a way to use your graveyard as a giant tutor pile, if you run creatures with various ETB effects, like Nekrataal, Mulldrifter, etc. I have a whole deck build around that idea, and once recurred a single Nekrataal over and over again turn after turn via dredging a Stinkweed Imp, saccing the 'taal, and switching the two with TE. The enchantment can also get you back a Maniac when you are ready to close the game.
Former Rules Advisor
"Everything's better with pirates." - Lodge
(The Gamers: Dorkness Rising)
"Any sufficiently analyzed magic is indistinguishable from science."
(Girl Genius - Fairy Tale Theater Break - Cinderella, end of volume 8)
Cards like Chronic Flooding, Pilfered Plans, Disrupt, and Psychic Drain are just not very good. You're spending a lot of cards and mana just to mill yourself slowly, without interacting with what the opponent is doing. Milling is also not good until you have a Lab Man out, otherwise you might just mill all your Lab Maniacs away and have no win condition! It's better to have cards that both interact with the opponent (or provide defense) and advance your gameplan (find Lab Man or mill yourself).
Drift of Phantasms and Stinkweed Imp are good, as already mentioned. Drift can either block OR find Lab Maniac, so it has 2 purposes. Stinkweed Imp can block and kill things and also mill you, so again it does 2 things. That's better than running a card that just mills you and does nothing else.
For a draw spell, Forbidden Alchemy is great at both digging through your library and milling you! And you can flashback copies you milled or cast. Fact or Fiction is great too. These spells will help you dig through your library to find the cards you want more efficiently. I would still run Opt because it lets you win immediately when you have no library, but Forbidden Alchemy and Fact or Fiction are much better than Pilfered Plans and some other cards.
Nephalia Drownyard is a reusable mill card you can fit into your manabase. You don't have to waste a spell slot on it. If you have extra mana and nothing else to do, you can use Drownyard to mill.
You want a way to return Lab Maniacs that were killed or milled. Dread Return is one way, but it is kind of combo-y and makes you suicide your own board. It's not so good if you don't plan to win that very turn. Corpse Churn is one way you can both mill yourself and bring back any Lab Maniacs you accidentally milled away. Liliana, Death's Majesty is another card that can both mill you and return any dead Lab Maniacs or walls. It also makes blockers and wipes the board, but it may be out of your budget.
Phenax, God of Deception works well to mill players when you're playing a Defender deck! You can also switch to milling the opponent if you want. It's a great win condition.