My biggest issue with Utter End versus Despark is 4 versus 2 mana, and CMC 4 or greater. If I'm in a competitive environment, 4 mana might be too much just for spot removal that doesn't exile...
But it does, though?
Also I don't think any of the permanents you listed get run hardly at all in true cEDH metas. Plenty in 75%-ish metas, of course (Although I think the gearhulks are mostly pretty mediocre).
The problem with utter end in a cEDH setting is that it's too slow to stop many combos. The problem with despark is that it doesn't hit many critical combo pieces. I don't really think either are good enough vs cEDH decks, to be honest.
Vs cEDH I think you need to use cheap, less flexible removal like stp, pte, nature's claim, pongify, etc and hope the types line up, since you can't always afford the flexibility tax. Or run tempo removal like bounce and unexpectedly absent, that won't solve the problem forever but can disrupt them at a critical time.
It's always a bit dependent on play patterns and meta. Primarily - how important answering early threats is, how many combos need to be interacted with at instant-speed and which specific pieces need to be answered, how much mana is reasonable to leave up, how much exile matters, etc.
Anguished Unmaking > Utter end, unmake, and morify, almost always. More flexibility at the cost, and the life loss is pretty irrelevant.
Personally I would consider vindicate to be the worst of all of them. Sorcery speed absolutely kills it imo. Instant-speed is way more effective against combo and lets you wait as long as possible for someone else to answer it, and to make sure it's really YOUR problem and not someone else's. On the other hand, it does hit lands. So some metas might want that enough to justify the other downsides. I guess it's still probably better than unmake, for the flexibility.
Despark is a little tougher since it really will depend on meta - many of the best combos totally circumvent it. But it is only 2 mana. So if you want to minimize mana kept up and aren't worried about food chain combos and like, it could be great. Maybe the best in a more casual environment since it lets you develop the most while keeping it up, and probably most stuff that really matters will cost more than 3.
But in vacuum...
I'd say anguished unmaking > despark > utter end > mortify > vindicate > unmake.
EDIT: also worth pointing out that I'd consider many mono-w and mono-b answers better than many of these, especially STP and PTE. I'm also a big proponent of oblation.
Also I don't think any of the permanents you listed get run hardly at all in true cEDH metas. Plenty in 75%-ish metas, of course (Although I think the gearhulks are mostly pretty mediocre).
The problem with utter end in a cEDH setting is that it's too slow to stop many combos. The problem with despark is that it doesn't hit many critical combo pieces. I don't really think either are good enough vs cEDH decks, to be honest.
Vs cEDH I think you need to use cheap, less flexible removal like stp, pte, nature's claim, pongify, etc and hope the types line up, since you can't always afford the flexibility tax. Or run tempo removal like bounce and unexpectedly absent, that won't solve the problem forever but can disrupt them at a critical time.
EDH Primers
Phelddagrif - Zirilan
EDH
Thrasios+Bruse - Pang - Sasaya - Wydwen - Feather - Rona - Toshiro - Sylvia+Khorvath - Geth - QMarchesa - Firesong - Athreos - Arixmethes - Isperia - Etali - Silas+Sidar - Saskia - Virtus+Gorm - Kynaios - Naban - Aryel - Mizzix - Kazuul - Tymna+Kraum - Sidar+Tymna - Ayli - Gwendlyn - Phelddagrif 4 - Liliana - Kaervek - Phelddagrif 3 - Mairsil - Scarab - Child - Phenax - Shirei - Thada - Depala - Circu - Kytheon - GrenzoHR - Phelddagrif - Reyhan+Kraum - Toshiro - Varolz - Nin - Ojutai - Tasigur - Zedruu - Uril - Edric - Wort - Zurgo - Nahiri - Grenzo - Kozilek - Yisan - Ink-Treader - Yisan - Brago - Sidisi - Toshiro - Alexi - Sygg - Brimaz - Sek'Kuar - Marchesa - Vish Kal - Iroas - Phelddagrif - Ephara - Derevi - Glissa - Wanderer - Saffi - Melek - Xiahou Dun - Lazav - Lin Sivvi - Zirilan - Glissa
PDH - Drake - Graverobber - Izzet GM - Tallowisp - Symbiote Brawl - Feather - Ugin - Jace - Scarab - Angrath - Vraska - Kumena Oathbreaker - Wrenn&6
Anguished Unmaking > Utter end, unmake, and morify, almost always. More flexibility at the cost, and the life loss is pretty irrelevant.
Personally I would consider vindicate to be the worst of all of them. Sorcery speed absolutely kills it imo. Instant-speed is way more effective against combo and lets you wait as long as possible for someone else to answer it, and to make sure it's really YOUR problem and not someone else's. On the other hand, it does hit lands. So some metas might want that enough to justify the other downsides. I guess it's still probably better than unmake, for the flexibility.
Despark is a little tougher since it really will depend on meta - many of the best combos totally circumvent it. But it is only 2 mana. So if you want to minimize mana kept up and aren't worried about food chain combos and like, it could be great. Maybe the best in a more casual environment since it lets you develop the most while keeping it up, and probably most stuff that really matters will cost more than 3.
But in vacuum...
I'd say anguished unmaking > despark > utter end > mortify > vindicate > unmake.
EDIT: also worth pointing out that I'd consider many mono-w and mono-b answers better than many of these, especially STP and PTE. I'm also a big proponent of oblation.
EDH Primers
Phelddagrif - Zirilan
EDH
Thrasios+Bruse - Pang - Sasaya - Wydwen - Feather - Rona - Toshiro - Sylvia+Khorvath - Geth - QMarchesa - Firesong - Athreos - Arixmethes - Isperia - Etali - Silas+Sidar - Saskia - Virtus+Gorm - Kynaios - Naban - Aryel - Mizzix - Kazuul - Tymna+Kraum - Sidar+Tymna - Ayli - Gwendlyn - Phelddagrif 4 - Liliana - Kaervek - Phelddagrif 3 - Mairsil - Scarab - Child - Phenax - Shirei - Thada - Depala - Circu - Kytheon - GrenzoHR - Phelddagrif - Reyhan+Kraum - Toshiro - Varolz - Nin - Ojutai - Tasigur - Zedruu - Uril - Edric - Wort - Zurgo - Nahiri - Grenzo - Kozilek - Yisan - Ink-Treader - Yisan - Brago - Sidisi - Toshiro - Alexi - Sygg - Brimaz - Sek'Kuar - Marchesa - Vish Kal - Iroas - Phelddagrif - Ephara - Derevi - Glissa - Wanderer - Saffi - Melek - Xiahou Dun - Lazav - Lin Sivvi - Zirilan - Glissa
PDH - Drake - Graverobber - Izzet GM - Tallowisp - Symbiote Brawl - Feather - Ugin - Jace - Scarab - Angrath - Vraska - Kumena Oathbreaker - Wrenn&6