Whenever Rankle, Master of Pranks deals combat damage to a player, choose any number —
• Each player discards a card.
• Each player loses 1 life and draws a card.
• Each player sacrifices a creature.
Quote from TechXT »As far as I understand, you have to do the effects in the order they are listed.
The main implication is that if they have no cards in hand you can't make them draw a card and then discard it.