Declaration and Nevermore can be destroyed by any deck if you run the colorless answers. Pyxis doesn't really do anything to commanders if Mindslaver effects don't take away the owner's choice about commander zone changes. I'm pretty sure if they cut out the mindslaver loophole, commanders will be available to cast from the command zone the whole game assuming you don't choose to put it the graveyard/exile for whatever reason and lose your way to get it back from there.
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Ban Mindlsaver or change a ruling