Yes, the card is designed and worded to allow you to do exactly that. Nothing stops you from activating the ability that exiles a card from your hand if there's already a card exiled, nothing breaks the link with the previously exiled card if you do, and the upkeep trigger tells you to copy a card exiled with Panoptic Mirror, which means any of the cards exiled with the first ability.
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I'm a former judge (lapsed), who keeps up to date on rules and policy. Keep in mind that judges' answers aren't necessarily more valid than those of people who aren't judges; what matters is we can quote the rules to back up our answers. When in doubt, ask for such quotes.
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